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Expression of neutrophil elastase in relation to the autoimmunity


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

Activated inflammatory cells, especially neutrophils, may play a significant role in pathology of autoimmune bullous dermatoses by secreting proteases, e.g. neutrophil elastase (NE). However, the role of NE in relation to autoimmunity against particular autoantigens (anti-DSG1/DSG3 IgG in pemphigus, anti-BP180/BP230 IgG in bullous pemphigoid - BP, anti-eTG/tTG/npG IgA in dermatitis herpetiformis - DH) has not been clearly explained. The aim of this comparative work was to attempt to clarify the intertwined issue of cutaneous autoimmune NE-mediated inflammation in those diseases. Six different study groups were investigated and a range of biochemical/molecular techniques was used. Computational analysis of microscopic images was used to measure the NE expression. Statistical analysis showed that the intensity of cutaneous NE expression in pemphigus and BP was significantly lower than in DH, but it was not significantly different in pemphigus and BP. It seems that cutaneous NE-related inflammatory processes in both pemphigus and BP, characterised by autoimmunity to structural proteins, have lesser pathologic importance in comparison with DH, characterised by autoimmunity to enzymes.

Product Specifications
SKU :COC26603
AuthorJustyna Gornowicz-Porowska
Number of Pages136
Publishing Year5/15/2012
Edition1 st
Book TypeMedicine
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-29 00:00:00