This study proposes a framework that can be used to design sustainable telemedicine information systems in Uganda and other developing countries based on Hevner et al. (2004) Design Science framework. The main contribution of the study is in the area of Information Systems design for sustainability from a developing country perspective. Two paper publications in top scientific journals have been realized from this study, listed as follows: . G.M. Kituyi, A.S. Rwashana, V.W. Mbarika and S.R. Isabalija (2011). Factors Affecting Adoption, Implementation and Sustainability of Telemedicine Information Systems in Uganda. Journal of Health Informatics in Developing Countries . G.M. Kituyi, A.S. Rwashana, V.W. Mbarika and S.R. Isabalija (2012). A Framework for Designing Sustainable Telemedicine Information Systems in Developing Countries. Emerald Journal of Systems and Information Technology.