University-Industry linkage is not a new concept. Several models exist for such a relationship. Despite that these models have been tested or used; they may remain unsuitable in certain countries and communities. With the unique situation of the Palestinians, the existing models cannot meet the specific needs and targets of establishing such a relationship. This project aims at building a framework for stronger relationships between Palestinian universities and industries based on a strong supporting platform of Science, Engineering, Technology & Innovation (SET&I). This would in turn strengthen the STE&I platform rendering it an enabled and enabling platform. The framework for the linkages positions the Palestinian Diaspora as the central driving force for successful implementation of the project. Taking into consideration Palestinian's constraints, the work also falls back onto the somewhat hidden strengths of the Palestinians, in Palestine and beyond. Many scenarios were discussed and the most appropriate was adopted. This is a framework that is hoped to be seen applied globally for all Palestinians, by the Palestinians.