A new approach for diabetic therapeutics

 

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  • Product Description
 

Diabetes is a worldwide pathology, characterized by a group of syndromes associated with very high levels of blood sugar. Pancreatic ?-cell maintains the blood glucose homeostasis by secreting insulin. The rise in cytosolic Ca2+ concentration due to extracellular Ca2+ influx through voltage-gated Ca2+ channels is the major trigger which stimulates insulin release and acts as a key regulator for insulin secretion. Ascorbic acid, the most common antioxidant shares structural similarity with glucose and have evidences that supplementation of ascorbic acid relieved various complications of diabetes. MIN6 (Mouse Insulinoma cell line) has been widely used as a ?-cell specific cell line which shows glucose stimulated insulin secretion qualitatively and quantitatively similar to normal ?-cells. This study specifically focused on the role of extracellular calcium and ascorbic acid individually as well as in association with each other in repairing, reactivation and rejuvenation of diabetic MIN6 cells first time. This effort sets up a ground work which can be further explored at molecular level and clinical trials, which will be helpful in therapeutics for type II diabetes in future.

Product Specifications
SKU :COC25157
AuthorPriyanka Sharma and Archana Tiwari
LanguageEnglish
BindingPaperback
Number of Pages88
Publishing Year2012-02-07T00:00:00.000
ISBN978-3659106064
Edition1 st
Book TypeClinical & internal medicine
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-28 00:00:00
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