The principle of the present research work is to carryout pre-clinical and open clinical study on Male infertility. Infertility is a couple’s inability to conceive a child after 12 months of unprotected sex. And it bears Social Stigma. It is widely assumed that infertility has more to do with women rather than men, however it is not so. Estimates suggest that 30% of infertility is caused by male factors, another 30% is caused by female factors and the remaining 40% is caused by a combination of female and male factors. The specific approach used to treat Male infertility depends upon number of factors like age, symptoms, Underlying factors and Semen analysis. The Herbal Siddha drug ‘Isabgol Chooranam’ has distinctive effect on Male Infertility, it increases the semen volume, viscosity and serum testosterone level in drug treated rat models and reduction of symptoms in Infertile Male Patients. These records confirm that the Siddha drug ‘Isabgol Chooranam’ can be used as a potential therapy for Infertile Man.