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AIDS and Pancreas in the HAART Era: A Cross Sectional Study


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

This study aims identify the main morphological patterns of pancreas in AIDS patients using Higly Active Antiretorviral Therapy (HAART). We compared adults who died of AIDS using HAART and underwent autopsy with 109 AIDS patients without HAART therapy. The HAART group presented lighter pancreas abnormalities than no HAART users. In the HAART group, histology shows: reduction of zymogen granules in the acinar cells (ZG), lower “dysplasia-like” and higher pancreatic acinar atrophy. The exocrine pancreas in treated patients was distinguished by the high level of atrophy, sharp reduction of zymogen granules and high level of apoptosis, reflecting degeneration and lower level of proteincaloric malnutrition. The islets of Langerhans in HAART group were increased in number and volume and with high level of nuclear dysplasia. The antiviral therapy and a longer survival resulted in a higher atrophy and reduction of enzymes, increasing the apoptosis and generated important changes in the pancreatic islets, probably resulting in clinical/laboratory repercussion. We found no evidence of pancreatic histological lesions secondary to antiretroviral therapy.

Product Specifications
SKU :COC60398
AuthorEthel Chehter and Alexandre Barbosa
Number of Pages76
Publishing Year29.09.2014
Edition1 st
Book TypeMedicine
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-05 00:00:00