Enzymes hold the future of biotech sector by contributing in research and industries. Enzymes obtained from microbes offer advantages over the enzymes obtained from plants and animals. Obtaining enzymes from plants and animal is a costly process while its easy to rear microbes in the artificial media under modifying physical and biochemical conditions and they show potential results. Since there is continuous need for finding new potential enzymes from microbe which offers immediate use in industries as well as in bioremediations. The spectrum of amylase application includes food, detergent, pharmaceutical, leather, textile, cosmetic, paper industries clinical, medical, analytical chemistry, distilling industries and bio-fuels industries. Keeping all these things in mind, the work was focused on finding enzymes from microbes with resistance towards pesticides, high salt concentrations, antibiotics and heavy metals for bioremediations and biofuel productions. Amylase produced by multiresistant microbes can be used for treatment of effluents with high salinity, pesticides contents and presence of heavy metals containing starch or cellulosic residues in pollution control mechanism.