Present findings reveals that one month treatment with selected dosage of Aloe vera extract is beneficial to counteract the alterations in antioxidant enzyme system, oxidative enzymes and lipid metabolic profiles in diabetic induced wistar strain rats. The oxidative enzymes also reversed back to normal values. The changes in markers of lipid profile and oxidative stress which include triglycerides, MDA content and total cholesterol indicate efficient altered machinery of oxygen species that was operated in the renal tissue in detoxification of antioxidant system that is produced due to diabetes. This study drawn a conclusion, stating that Aloe vera treatment to diabetic induced rats may be beneficial to improve the metabolic efficiency and thereby improve the health status. Thus Aloe vera may be useful in the formulation of herbal drugs which can be used in the treatment of diabetes. Since Aloe vera exhibited antioxidant and antidiabetic activity; it might be clinically useful in the control of human diabetes. Successive studies are mandatory to establish the precise nature of Aloe vera active constituents as well as their mechanism of action.