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AMPK in the regulation of autophagy, cancers and cellular transport


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

The nutrient and energy sensor AMP-activated protein Kinase regulates cellular and whole-body energy homeostasis through stimulating catabolic ATP-generating and suppressing anabolic ATP-consuming pathways thereby helping cells survive during energy starvation. AMPK plays an important role in autophagy induction in response to starvation, a process that involves phosphorylating TSC2 and mTOR activation. Recent advances indicate the kinase also to exert tumor suppressor activity by stimulating apoptosis, autophagy and cell growth and proliferation. AMPK can be used to protect from metabolic syndrome. This kinase has previously been demonstrated to be either directly or indirectly involved in the regulation of numerous carriers, channels and pumps of high relevance for cellular physiology and pathophysiology. Thus, AMPK provides a necessary link between cellular energy metabolism and cellular transport activity. Better understanding of the AMPK role in the regulation of cell transport under physiological and pathological conditions may represent a potential for developing therapies for many human diseases and disorders, especially cancers.

Product Specifications
SKU :COC78028
AuthorMentor Sopjani
Number of Pages76
Publishing Year2014-08-26T00:00:00.000
Edition1 st
Book TypeMathematics & science
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00
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