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Amyloidogenic Proceses Of Intrinsically Disordered Proteins

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Many untreatable neurodegenerative human disorders, like Parkinson’s, Alzheimer’s, and prion diseases, are associated with the aggregation of misfolded or natively unfolded proteins into amyloid fibrils. Cells have adapted two main sophisticated quality-control measures to protect against these protein aggregation processes: the molecular chaperones against the misfolded protein conformations that trigger the aggregation, and the ubiquitin-proteasome system to degrade those proteins that remain misfolded. Despite these natural defense mechanisms amyloidoses may very soon be the most prevalent and socially disruptive illness in the aging population. Currently available therapies against these diseases can neither arrest nor reverse their progression: only the symptoms can be managed. Most current efforts to develop new therapeutics are based on antibodies or synthetic molecules with sufficiently high affinity to compete against, and to inhibit the aggregation of proteins and/or to potentially dissolve their aggregates, once they are formed.

Product Specifications
SKU :COC77430
AuthorDhruv Kumar,Marco Brucale and Bruno Samori
LanguageEnglish
BindingPaperback
Number of Pages124
Publishing Year2014-09-04T00:00:00.000
ISBN9783659592928
Edition1 st
Book TypeBiophysics
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00