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Analysis of Breast Cancer Stem Cells Heterogeneity

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Cancer stem cells (CSC) have been detected in breast tumours and in breast cancer cell lines; they are a subpopulation of tumour cells with tumour initiating capacity, which self-renew and give rise to progeny that constitute the tumour bulk. It has been suggested that CSCs are major drivers of relapse after treatment because they are relatively resistant to drug- and radiation-induced cell death. Analysis of breast cancer stem cells has a major significance in the field of cancer therapy. From a therapeutic perspective, it is important to focus on the CSC population most responsible for tumour initiation, metastasis and relapse. But it is not currently clear which characteristics most define the highly tumorigenic population. Regarding this, my project focused on two main characteristics of CSCs: expression of pluripotency factors such as OCT4, and slow cycling properties using existing breast cancer cell lines MCF7 and MDA-MB-231 that are known to contain a CSC population.Also, I attempted to leverage the marine bioproducts expertise of the Medical Biotechnology Department, and the Flinders Centre for Marine Bioproducts Development to screen for novel sponge-derived chemicals.

Product Specifications
SKU :COC77567
AuthorEaman Alghamdi
LanguageEnglish
BindingPaperback
Number of Pages108
Publishing Year2014-03-28T00:00:00.000
ISBN9783848405411
Edition1 st
Book TypeBiology, life sciences
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00
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