Among phosphorus containing pharmaceutical compounds, bisphosphonates is a very important class. Therapeutic uses of bisphosphonates include maagement of malignancy-associated hypercalcemia, treatment of postmenopausal osteoporosis and cancer. Bisphosphonates, as a group of active pharmaceutical compounds, generally "give headache" to analytical chemists. The two phosphonic groups per molecule lend a strongly ionic character and increased polarity to these compounds. Additionally, the majority of the members of this family lacks of chromophores, or even has a weak one, excluding convenient sensitive UV or fluorescence detection.This work is devoted to the determination of three bisphosphonate drugs commercially available in the local Egyptian market (alendronate, etidronate and risedronate.The usefulness of different spectrophotometric and chromatographic methods was exploited.The proposed methods are of great value in quality control analysis of the studied compounds owing to their improved simplicity, sensitivity, low-cost, and its independence on expensive instruments, or critical analytical reagents.