To develop & validate UV & HPLC methods for simultaneous estimation of Cefpodoxime Proxetil & Levofloxacin Hemihydrate in bulk drug and pharmaceutical dosage form.By application of analytical tequniques like various UV methods and HPLC for simultaneous estimation of CPD& LVX like Simultaneous equation method, Q-absorbance ratio method, First order derivative method and RP-HPLC method. Developed methods were applied to perform analysis of marketed formulation (Glevopod). Validation of developed methods was performed according to ICH Q2 (R1) guideline. Comparison of all developed and validated methods were carried out by using statistical tools.These all methods are sensitive, selective, accurate, precise and rapid for the simultaneous estimation of CPD & LVX in Bulk drug and Pharmaceutical dosage form. It can be successfully adopted for routine Q.C. analysis of two drugs in pharmaceutical dosage form without any interference from common excipients and impurity.