This book has explained the introduction of antidepressants, their types, analytical methods of determination as well as kinetic studies. Simple procedures to determine the first generation antidepressant drugs such as Amitryptylene, desipramene, imipramine are well explained. Kinetic data in presence of drugs and surfactants have been the excellent findings of this work. The drugs and there behaviour towards surfacts have been study very efficiently. The effect of different surfactant and there behaviour towards urea and general cancer treatment drugs such as hydroxamic acid have been studied.