BSL could be a promising anti-initiation agent in vitro through inhibition of CYP 1A mediated carcinogen metabolism and induction of GST activity as well as GSH level. BSL also possesses anti-inflammatory activity through its capacity to enhance macrophage proliferation rate and its ability to inhibit stimulated NO, TNF-α and COX-2 levels. Besides preventing tumor promotion, BSL showed inhibitory activity toward DNA fragmentation and cytotoxic property against Hep-G2 tumor cell line as anti-progression properties. In vivo administration of BSL before and after DEN induction showed inhibitory activity toward HDAC and lipid peroxidation which induced by DEN. Also, BSL modulates GST-P expression which upregulated with DEN injection. It resulted in a significant increase in GST activity and GSH level. It downregulates TNF-α level and induced apoptosis. Anti-progression properties of BSL represented by its inhibitory activities to DNA fragmentation and VEGF where PDGF level was unaffected. Furthermore, . Garlic showed an induction in GST activity and GSH level and it increases TNF-α and decreases VEGF level.
|Author||Azza El Amir|
|Number of Pages||144|
|Country of Manufacture||India|
|Product Brand||LAP LAMBERT Academic Publishing|
|Product Packaging Info||Box|
|In The Box||1 Piece|
|Product First Available On ClickOnCare.com||2015-10-08 00:00:00|