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Anti-HIV Bioadhesive Vaginal Film And In Vitro-in Vivo Correlation


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

The aim of the current study was to establish the In vitro-invivo performance after selection of vaginal modified-release dosage form. The present study concerned with the development and characterization of bioadhesive vaginal film (ZLF). Zidovudine (AZT) containing ZLF. The results demonstrate good correlations between in vitro drug release and in vivo drug absorption. Zidovudine (AZT) containing ZLF were prepared by solvent casting method using different ratios of sodium alginate, Hydroxy propyl methyl cellulose (HPMC) and Glycerol as a plasticizer. The optimized films were found to be transparent, flexible and soft and evaluated for mechanical properties by modifying the instrument, drug content, folding endurance, in-vitro and In-vivo drug release with release kinetic and % moisture content bioadhesive strength by modified pan balance method. Drug delivery through vaginal films is a promising area for continued research with the aim of achieving controlled release with enhanced bioavailability over longer periods of time. Further research, in this area will surely expected to yield a significant outcome with improved vaginal drug delivery system, for treatments of AIDS.

Product Specifications
SKU :COC85033
AuthorArkendu Chatterjee and Benoy Bratha Bhowmik
Number of Pages92
Publishing Year2013-03-28T00:00:00.000
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00