Inflammation is a complex pathophysiological process mediated by a variety of signaling molecules produced by leucocytes, macrophages and mast cells as well as by the activation of complement factors that bring about edema formation as a result of extravasation of fluid and proteins and accumulation of leucocytes at the inflammatory site and rheumatoid arthritis (RA) is a chronic debiliating autoimmune disorder that affects about 2.1 million Indians and Americans etc. Its etiology is still un- known. However, RA is characterized by a systemic inflammatory state, involving several organs, including joints, skin, eyes, lung and blood vessels. Immune cells and soluble inflammatory mediators play a crucial role in RA pathogenesis. Various leucocyte populations, orchestrated by several cytokines, chemokines, growth factors and hormones, infiltrate rheumatoid tissues and increase injury.