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Anti-tubercular Drug Design Exploring Mycobactin Biosynthetic Pathway


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

“since a growth factor for Mycobacterium paratuberculosis was produced by Mycobacterium tuberculosis and seemed highly specific for the mycobacteria, its structure, if known, should provide a highly suitable model for the synthesis of compounds having a specific action against the mycobacteria” ..... Francis, J (1945) in Bacteriol Rev, 1970, 34, 99-125 by Snow, GA *****Small molecule heterocyclic compounds that mimics hydroxyphenyl oxazoline portion of mycobactin were designed to interfere mycobactin biosynthesis. Mycobactin is a mycobacterial "siderophore" responsible for iron acquisition from host cell. Iron and mycobactin are two important virulence factors and restricting the iron acquisition by blocking the mycobactin biosynthesis will in turn affect the growth of mycobacteria inside the host cell. A library of around thirty-nine molecules were synthesized and tested for their anti-tubercular activity under iron rich and deprived media. *****

Product Specifications
SKU :COC85196
AuthorVenkatesan Jayaprakash and Barij Nayan Sinha
Number of Pages72
Publishing Year2013-10-02T00:00:00.000
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00