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Anti-tumor vaccine and immunotherapy based on CD4+ T helper cells

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Vaccination with poorly or not immunogenic tumour cells failed to protect the host from a subsequent challenge in animal models. The mechanisms underlying the failure of these cells to sensitize the therapeutic T cells are not clearly understood, but the inability of the host T cells to recognize the cancer has been implicated. Previous works have shown that an highly aggressive murine mammary adenocarcinoma can be rejected by the host if genetically modified to express MHC class II genes upon transfection of the MHC class II transactivator, CIITA. MHC class II molecules are required for presenting antigenic peptides to the T helper cells and thus activate the cascade of events leading to immune effector functions, such as antibody production and cytolytic T cell activity. The purpose of this work is to investigate whether the above approach could be generalized and thus extended to tumours of different histological origin. Moreover, it was assessed whether anti-tumour lymphocytes generated by this approach could be used as an immunotherapeutic tool for established cancers in different murine models.

Product Specifications
SKU :COC87386
AuthorValeria Frangione
LanguageEnglish
BindingPaperback
Number of Pages76
Publishing Year2013-12-22T00:00:00.000
ISBN9783659506741
Edition1 st
Book TypeBiology, life sciences
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00