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Antiapoptotic Strategies in Retinal Degeneration

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

The sphingolipid ceramide exerts a pro-apoptotic role in variety of cellular and organ systems and increased of de-novo synthesis of ceramide are associated with initiation of cell death. In Retinitis Pigmentosa (RP) photoreceptor death occurs by apoptosis but the individual pathways of this process are unknown. We employed an animal model of RP, the rd10 mutant mouse, to assess the role of ceramide in inherited photoreceptor degeneration. We used Myriocin, a known inhibitor of serine palmitoyltransferase (SPT, the rate-limiting enzyme of ceramide biosynthesis) which was either injected intravitreally in a single dose or administered daily to rd10 mice as eye drops of Solid Lipid Nanoparti- cles (SLNs). Control mice were given intravitreal injections of vehicle alone or unloaded lipid particles, respectively. We found that retinal ceramide levels in rd10 mice double from P14 to P30, the time interval of maximum photoreceptor death in this strain. Intraocular treatment with Myriocin decreases the number of pycnotic photoreceptors in rd10 mice by approximately 50%. Electroretino- gram (ERG) recordings were obtained from animals of various ages chronically treated with Myriocin-SLNs.

Product Specifications
SKU :COC87231
AuthorIlaria Piano and Claudia Gargini
LanguageEnglish
BindingPaperback
Number of Pages72
Publishing Year2013-05-11T00:00:00.000
ISBN9783659395994
Edition1 st
Book TypeBiology, life sciences
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00