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Anticancer Properties of Novel Synthetic Vanillin Derivatives

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Benzyl-o-vanillin and benzimidazole nucleus serves as an important pharmacophore in drug discovery as it have a significant medicinal importance. Thus we explored the anticancer activity of three relative compounds and found their structure activity relationship compare with 2-benzyloxy-3-methoxybenzaldehyde main structure. According to the cytotoxicity analysis, they induce cell death of leukemic cell line through DNA fragmentation. DNA binding studies reveals that the DNA binding occurs through groove region. The higher mutagenicity might cause DNA mutation through interaction with the guanines while the lack of significant mutagenic activity suggests that the compound may target mainly the AT rich sequences of the nucleic acid. Hence, the present study provides a new insight of these novel (2-benzyloxy-3-methoxyphenyl) derivatives serving as a potential therapeutic agent against leukemia. This work should help shed some light on these exciting compounds and their SAR results, and should be especially useful to professionals in Oncology and cancer research feilds, or anyone else who may be considering utilizing DNA-drug interactions along with mutagenicity for research effort.

Product Specifications
SKU :COC41763
AuthorZena A. Abdul Hameed Al-Mudaris,Amin Abdul Majid and Sedigheh Mehrabian
LanguageEnglish
BindingPaperback
Number of Pages164
Publishing Year2012-06-08T00:00:00.000
ISBN978-3659167713
Edition1 st
Book TypeGenetics (non-medical)
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-03-08 00:00:00
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