To study the antioxidative, antitumor and immunomodulatory activity of protein fractions of leaves of Cynodon dactylon and Terminalia catappa on Swiss albino mice. The protein fractions were administered intraperitoneally in mice. The antioxidative and antitumor activity were analysed by liver marker enzymes, enzymic and nonenzymic antioxidants, lipid peroxidation and histological status of liver. The assessment of immunomodulatory activity on humoral and cell mediated immunity were studied by lymphoid organ weight, total leukocyte count, neutrophil adhesion, phagocytic index, antibody titre and protein profile. The results of the study suggested the antioxidative efficacy by enhancing the antioxidative enzymic and non enzymic status, antilipidperoxidative role by inhibiting the lipid peroxide status, antitumorigenic against ELA tumor by increasing the ILS and immunostimulatory against the pyrogallol by the enhancement of the humoral and cell mediated immune responses by the administration of C. dactylonPF and T. catappaPF. Thus Cdpf and Tcpf could be exploited as an antioxidative, antitumorigenic and immunostimulatory agents to combat the oxidative degenerative diseases.