Apoptosis, a type of "Programmed Cell Death" is a tightly regulated essential event of the life process of a cell. However, induced apoptosis in normal cell often causes damage to the system leading to several critical disorders. With the increasing load of environmental contaminants, arsenic and mercury are of special attention world wide including India and Bangladesh. Beyond conventional toxicological studies, molecular mechanism underlying arsenic and mercury induced apoptosis in rat hepatocytes has been depicted here. Moreover, free radical induced apoptotic signals and relationship with cellular thiol homeostasis has been demonstrate.The goal is to understand the regulatory mechanism of heavy metal induced free radical toxicity and apoptosis as well as to identify the targets in order to inhibit cell death.There is an ample scope and immense need to proceed further in this area. Amalgamation and computation of the innovative research outcome is also of significant importance which will serve as a platform of future study. Looking forward to participate in any shots of exchange of ideas.