Applications of Novel Substituted Biphenyl-Sulfonamides

Applications of Novel Substituted Biphenyl-Sulfonamides


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The objectives of this work is comparing three different kinds of sulfonamide compounds by evaluating structure modification through their examination towards more important properties such as: (a) Surface properties of the synthesized sulfonamide compounds were studied through surface parameters ?cmc,(cmc), A(min) and ?(max). Most of these tested compounds have remarkable surface activity. (b) The target compounds were tested to determine structure-biological activity relationship against different types of pathogenic bacterial species. The amine acid salts of bis (2-aminophenyl) biphenyl-4,4''-disulfonamide (Series B) were the powerfully effective series. Only carboxylic acid salts of bis (2-aminophenyl)biphenyl-4,4''- disulfonamide (Series B) were powerfully effective series against selected pathogenic fungal species. (c) Selected compounds were screened for cytotoxicity against selected human tumor cell lines – MCF7, HEPG2, and HCT116. Most of tested compounds have potent cytotoxic activity against liver carcinoma and colon carcinoma, meanwhile, exhibit moderate activity against breast carcinoma.

Product Specifications
SKU :COC49265
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-04-08
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