Arsenicosis is one of the major problem among the people who are living with arsenic contaminated zone usually in South East Asia. It is not only contaminated by water. It can be contaminated by other sources as air and food as well. Chronic effect of arsenic poisoining may lead to various skin and systemic problem even carcinoma. It is very difficult to manage. Early detection and treatment is very important for management. The most immportant is to prevention is better then cure is the motto for arsenicosis management.