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Assessment of Cell Proliferation in Liver Allograft Rejection

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Liver transplantation remains the only definitive treatment for patients with end stage liver disease. In this study the proliferative activity of hepatocytes and lymphocytes were investigated in liver biopsies of post-transplant patients with acute and chronic rejection as well as recurrent hepatitis C. A higher proliferation rates of hepatocytes and lymphocytes were seen in allograft rejection cases suggesting a in situ source of activation and priming of lymphocytes. The utility of ki-67 proliferation marker in differentiating recurrent HCV from acute rejection was also investigated. Ki-67-labeled portal tract lymphocytes were higher in acute rejection and can be used as a good positive test in differentiating both diseases. Differentiating both conditions may represent a diagnostic dilemma in post-transplant biopsies with a major influence in deciding proper treatment, as raising level of immunosuppression or introducing interferon therapy are two contradictory measures. The use of ki-67 for staining of portal lymphocytes when combined with image analysis technique may prove useful as an adjuvant in diagnosis.

Product Specifications
SKU :COC94791
AuthorSameh Abou-Beih
LanguageEnglish
BindingPaperback
Number of Pages268
Publishing Year2011-10-17T00:00:00.000
ISBN978-3846530672
Edition1 st
Book TypeMedicine
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-14 00:00:00