Kepulauan Seribu or The Seribu Islands, Indonesia, also known in English as the Thousand Islands, consisting of 106 islands, is located to the north of Jakarta, the capital city of Indonesia. This book assess and focuses on spatial analysis using Geographic Information System (GIS) data on physical/biophysical change, and is carried out in conjunction with qualitative analysis of socio-economic and governance factors between 1965-2012, including reviewing ocean and coastal policies in Indonesia. The history of spatial changes in the study area are used for identifying the vulnerability indicators and qualitatively assessing them in terms of socio-economic factors. Governance factors added valuable information for enhancing the accuracy and validity of the results. It is found that the policies designed to maintain the balance of social, economic and environmental impacts on the region have failed to protect the region from change. The ambiguity and powerlessness of law enforcement is another factor responsible for environmental damage in the region.