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AUG start codon recognition by bacterial ribosomes


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  • Product Description

Initiation is the rate-limiting step of translation and is an important regulatory step in gene expression. Translation initiation requires ribosome recognition of the mRNA’s start codon followed by formation of a stable ternary complex involving initiator tRNA. Studies have shown specific contacts between a AUG start codon and several ribosomal proteins (r-proteins). We employed short-leadered mRNAs in order to further characterize the path of an mRNA’s 5’-AUG from initial association with the ribosome to its final placement at the ribosome’s decoding site (P-site). Our results suggest that bacterial ribosomes can bind and inspect the 5’-terminus of all mRNAs for an AUG triplet, with close proximity of AUG to the 5’-terminus positively influencing ribosome binding and ternary initiation complex formation. Crosslinking studies showed that while 5’-AUG interactions with r-proteins S1, S3, S4, S7, S10 and S18 can occur in the absence of tRNA-fMet, movement of a 5’-AUG into the Psite requires tRNA-fMet.

Product Specifications
SKU :COC89890
AuthorKarthik Krishnan
Number of Pages148
Publishing Year2013-02-13T00:00:00.000
Edition1 st
Book TypeMicrobiology (non-medical)
Country of ManufactureIndia
Product BrandScholars' Press
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00
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