Auto-immunity in Colorectal Cancer: Anti-p53 and anti-hTERT antibody

 

Marketed By :  Scholars' Press   Sold By :  Kamal Books International  
Delivery in :  10-12 Business Days

 

Check Your Delivery Options

 
Rs. 5,655

Availability: In stock

 
  • Product Description
 

Carcinogenesis is a multi-aetiological process involving alterations of key biomolecular markers. These are recognised by the humoral system and known as Tumour Associated Antigens (TAA) against which the humoral system mounts an auto-antibody response. Cancer cells are subject to two key mortality barriers (M1 & M2) as described in the “2-hit” hypothesis. These are overcome by p53 dysfunction in M1 and hTERT re-expression in M2. Auto-antibodies are produced in response to these two TAA. This book investigates the significance of the anti-p53 and anti-hTERT auto-antibody response. The initial literature review of anti-p53 auto-antibody in all cancers (1979-2010) forms the largest body of evidence of correlation between anti-p53 auto-antibody and p53 mutation to date. This is followed by results of our anti-p53 study and evaluation of all published studies of anti-p53 in colorectal cancer. Anti-hTERT has only been reported once, using molecular recombination to develop the hTERT antigen. The latter section of this book aims to develop a less restrictive technology for mass detection of anti-hTERT. This humoral response could enable earlier identification of CRC and impact prognosis.

Product Specifications
SKU :COC84546
AuthorAravind Suppiah
LanguageEnglish
BindingPaperback
Number of Pages272
Publishing Year2013-07-02T00:00:00.000
ISBN9783639515206
Edition1 st
Book TypeMedicine
Country of ManufactureIndia
Product BrandScholars' Press
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00
0 Review(s)