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Automated protein complex modelling

 

Marketed By :  Südwestdeutscher Verlag für Hochschulschriften   Sold By :  Kamal Books International  
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  • Product Description
 

Protein interaction networks provide an increasingly complex picture of the relationships between macromolecules in the cell. Complementing these interactions with structural data provides critical insights into interaction mechanisms. However, structural information is available only for a tiny fraction of protein interactions and complexes currently known. A method is developed here to predict macromolecular complex structures by systematic combination of pairwise interactions of known structure. An efficient algorithm was designed that exploits heuristics to reduce the large search space. This is complemented with an automated scoring system to filter out the exponentially large number of unrealistic complexes, leaving a ranked set of the most plausible models. On a benchmark set of complexes of known structure, many complexes can be re-created with high accuracy and certain models are much larger and more complete than what is possible with traditional modelling techniques. As the rate of structurally resolved interactions grows, the ability to model larger and more diverse complexes will grow exponentially.

Product Specifications
SKU :COC71844
AuthorChad A. Davis
LanguageEnglish
BindingPaperback
Number of Pages100
Publishing Year2011-01-28T00:00:00.000
ISBN978-3838123769
Edition1 st
Book TypeComputing & information technology
Country of ManufactureIndia
Product BrandSüdwestdeutscher Verlag für Hochschulschriften
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00