Hypertension and type-2 diabetes are interrelated metabolic disorders that strongly predispose an individual to atherosclerotic cardiovascular disease and to renal failure. Hypertension is likely twice as common in subjects with diabetes compared to those without. Currently, there is considerable need for safe agents that can reduce risk for diabetes and hypertension without any adverse effects. However, several functional foods and natural herbal remedies have potential in this regard. Yogurt which is an established functional food, it is fermented milk that contains probiotic bacteria. In recent years, there has been increasing interest in the use of natural food additives and incorporation of health-promoting substances into the diet. Medicinal plants play an important role in the treatment of diabetes and hypertension. The purpose of the present study was to assess the inhibitory potentials of Azadirachta indica-yogurt as anti-diabetic and as anti-hypertension. Several quantitative measurements were also carried out on the A. indica- yogurt to quantify the total phenolic content, estimation of antioxidant capacity and peptide content.