Bacterial P450s and steroid transformations

Bacterial P450s and steroid transformations


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
Delivery in :  10-12 Business Days

₹ 4,396

Availability: Out of stock


Delivery :

5% Cashback on all Orders paid using MobiKwik Wallet T&C

Free Krispy Kreme Voucher on all Orders paid using UltraCash Wallet T&C
Product Out of Stock Subscription

(Notify me when this product is back in stock)

  • Product Description

Four bacterial cytochrome P450 enzyme activities are described in terms of their potential biotechnological use for steroid transformations, by engineered ''Rhodococcus'' strains, into commercially valuable compounds. Three selected rhodococcal P450s were characterized with microbiological, genetic, biochemical, spectroscopic and chromatographical methods. Two sterol C26- hydroxylases were demonstrated to be important for 3- hydroxysterol degradation. The role of the novel dextromethorphan N-demethylase in sterol metabolism was discussed. Furthermore, heterologous production of a mutated P450 enzyme, from ''Bacillus megaterium'', was shown in an engineered ''Rhodococcus'' strain. The activity of the mutated P450 was identified as 16?-hydroxylase of 4- androstene-3,17-dione, by ?H and ??C NMR. The detailed characterization of the cytochrome P450 enzymes, described in this book, provides insight into the catabolic repertoire of selected bacterial strains, necessary for engineering of steroid catabolic pathways in order to produce pharmaceuticals efficiently.

Product Specifications
SKU :COC100694
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-18
0 Review(s)