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Bacterial P450s and steroid transformations

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Four bacterial cytochrome P450 enzyme activities are described in terms of their potential biotechnological use for steroid transformations, by engineered ''Rhodococcus'' strains, into commercially valuable compounds. Three selected rhodococcal P450s were characterized with microbiological, genetic, biochemical, spectroscopic and chromatographical methods. Two sterol C26- hydroxylases were demonstrated to be important for 3- hydroxysterol degradation. The role of the novel dextromethorphan N-demethylase in sterol metabolism was discussed. Furthermore, heterologous production of a mutated P450 enzyme, from ''Bacillus megaterium'', was shown in an engineered ''Rhodococcus'' strain. The activity of the mutated P450 was identified as 16?-hydroxylase of 4- androstene-3,17-dione, by ?H and ??C NMR. The detailed characterization of the cytochrome P450 enzymes, described in this book, provides insight into the catabolic repertoire of selected bacterial strains, necessary for engineering of steroid catabolic pathways in order to produce pharmaceuticals efficiently.

Product Specifications
SKU :COC100694
AuthorKamila du Plessis
LanguageEnglish
BindingPaperback
Number of Pages156
Publishing Year2011-04-27T00:00:00.000
ISBN978-3844330779
Edition1 st
Book TypeMicrobiology (non-medical)
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-18 00:00:00
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