This book presents a brief introduction to the conceptual basis of stereochemistry, it is necessary to understand some of the language used to describe stereochemistry. Stereochemistry is an important branch of chemistry that studies the orientation in space of the atoms of a molecule. Also, stereoisomers are molecules that differ from each other by the arrangement in space or the geometry of atoms in the molecule. This book contains some important topics include types of geometrical isomerism, carbon hybridization, the Ingold rules, determination of the configuration of geometrical isomers, synthesis of molecules with a specific optical activity, optical isomers due to chirality, conformational analysis of both alkanes and alicyclic compounds and much more. In addition to figures, equations and schemes, it is profusely illustrated with some examples both historical and current. This book is useful to professionals in organic chemistry and will help the chemistry students.