"Fighting cancer is our goal. We can do it it?s in our soul" Despite recent success toward discovery of more effective anticancer drugs, histone deacetylase (HDAC) inhibition plays an important role for the treatment of cancer. HDACs are the part of extensive member of enzymes that have essential biological role mainly through their inhibiting influence on transcription. In this review, we have mainly focus on benzamide based HDAC inhibitors with their synthesis pathways and their biological screening. This review summarizes synthesis of various benzamide derivatives and their evaluated HDAC inhibitory efficacy in terms of IC50 values.