Aloe is also an excellent treatment for skin conditions such as burns and eczema. It is often reported that burns can be healed remarkably quickly and the pain reduced very quickly with topical application of Aloe Vera to the burn area. As well as applying topically, Aloe can also be taken internally so it is just as useful for internal epithelial tissue as it is for the skin. Aloe works on membranes and surfaces. Aloe also seems to be excellent at regulating the immune system (an immunomodulator). This means it can both stimulate the immune response for those with weakened immune systems either from exisiting conditions or post-illness fatigue. It can also calm the immune response, such as for Hayfever where less immune reaction is beneficial. There is no single ingredient that makes it very potent and healthful. Researcher Robert Davis, Ph.D., an endocrinologist-biologist, explains that fifteen different compound groups of nutrients work together to make the plant effective. This means that Aloe vera's effects cannot be synthesized easily in a laboratory. On the upside, this makes the plant useful across a wide spectrum of circumstances. And because the various elements that make it effective are nutrients rather than drugs, the juice may complement medical treatments. In fact some cancer patients state that Aloe vera seems to reduce nausea, increase energy, and may help to minimize low blood counts caused by chemotherapy or radiation.