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Bioadhesive Microspheres as Sustained Release Drug Delivery System

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Mucoadhisive microcapsules are proposed for the antidiabetic drug glipizide, to obtain controlled release. Glipizide microcapsules with a coat consisting of pectin was prepared by employing ionic gelation process and emulsification ionotropic gelation process. The microcapsules were evaluated for flow properties, Carr’s index, hausner ratio, micro encapsulation efficiency, drug release characteristics, surface characteristics; compatibility studies mucoadhesive properties. Pectin is a polysaccharide with a variable molecular weight. In the presence of calcium ions, pectin forms a gel of calcium pectinatethat are more resistant to disruption in the gut than alginate gel. Researchers have formulated oral controlled release products of glipizide by various techniques. Dosage forms that are retained in the stomach would increase the absorption, improve drug efficiency and decrease dose requirements. Thus, an attempt is made in the present investigation to use chitosan as a mucoadhesive polymer and prepare microspheres. The microspheres will be characterized by in-vitro and iv-vivo tests and factorial design will be employed to optimize the variables.

Product Specifications
SKU :COC31542
AuthorMaizbha Uddin Ahmed,Sharif Mahmood and Mohammad Safiqul Islam
LanguageEnglish
BindingPaperback
Number of Pages116
Publishing Year2012-11-10T00:00:00.000
ISBN978-3659263545
Edition1 st
Book TypePharmacology
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00