In the quest for natural remedies for sustained wellness and good health, Science has been required to look at unorthodox sources from the plethora of fauna and flora. The mushroom was initially viewed as a decorative, sometime toxic, fairy stool to be admired and then ignored but, of late, this dictum has had to be re-examined. The mushroom is now, landed as a fountain head of numerous, wondrous biomolecules which have a spectrum of significant biochemical properties. This literary work is an emphatic tribute to the miracle of nature – the mushroom. The author has endeavoured to emphasize the nutritional and biochemical properties of mushrooms highlighting the tremendous potential with respect to wee-being management and betterment of Mankind.