Shorttitle Biological terrorism has become more immediate and concern about new strains of pathogens has increased in the world . Human exposure to these agents may occur through inhalation, skin (cutaneous) exposure, or ingestion of contaminated food or water. Biological warfare agents may persist in the environment and cause problems some time after their release.The agents below fall into four major groups, three classes of microorganisms - bacteria, rickettsia, and viruses, plus bacterial toxins, which are poisonous chemicals produced by bacteria. The important diseases resulted from bioterrorism taken in this presentation which including anthrax , plague , Cholera , smallpox and Influenza . The world need increased training and education of health care professionals on how to prevent and treat biological warfare casualties. The potency of Bacillus preparation was determined against Spodoptera littoralis. Recombinant crystalline protein and endospores from bacterial transconjugants were highly toxic against S. littoralis than from their parental strains.