Call Us 080-41656200 (Mon-Sat: 10AM-8PM)
Free Shipping above Rs. 1499
Cash On Delivery*

Bioconversion of Berberine for enhanced inhibition of Phospholipase A2

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
Delivery in :  10-12 Business Days

 

Check Your Delivery Options

 
Rs. 5,066

Availability: In stock

 
  • Product Description
 

This monograph explains the role of fermentation in the preparation of Ayurvedic medicines. Berberine, an alkaloid was identified by X-ray crystallography as an inhibitor of phospholipase A2, an enzyme involved in inflammatory response. It was subjected to biotransformation by microorganisms and the product exhibited almost 30% enhanced inhibition of phospholipase A2 compared to the native alkaloid. The crystal structure showed that the product, dihydroxy berberine, binds at the active site of the enzyme in a longitudinally inverted orientation of the binding of the native molecule. The inert methoxy group of berberine became the site of interaction by biotransformation. The modification of methoxy group to hydroxyl group, made the binding of the berberine to the enzyme stronger. This explains the higher phospholipase A2 inhibitory activity of biotransformed berberine, hence, the role of fermentation in production of certain poly herbal formulations.

Product Specifications
SKU :COC36243
AuthorM. Haridas and D. Naveen Chandra
LanguageEnglish
BindingPaperback
Number of Pages172
Publishing Year11/15/2012
ISBN978-3659298035
Edition1 st
Book TypeBiophysics
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-31 00:00:00