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Biodegradable Gels of Insulin


Marketed By :  VDM Verlag Dr. Müller   Sold By :  Kamal Books International  
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Rs. 4,396

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  • Product Description

The objective of the study was to develop a controlled release dosage form of insulin, which can provide basal concentrations of insulin in diabetic rats for 1 to 2 weeks after a single subcutaneous injection. A biodegradable injectable drug delivery gel was prepared by dissolving a biodegradable polymer, polylactic-co-glycolic acid (PLGA), in biocompatible plasticizer(s), triethyl citrate (TEC) and/or acetyl triethyl citrate (ATEC). Insulin or modified insulin was then loaded into the blank gel to form insulin or modified insulin suspension in the polymer solution. After the insulin-loaded gel was injected subcutaneously, the insulin or modified insulin was released slowly from the depot by a combination of drug diffusion and erosion of the polymer. The formulation prepared with 5% PLGA, ATEC: TEC (3:1) and 4% modified insulin glargine was able to suppress the blood glucose concentrations of the ZDF rats significantly for 10 days after a single subcutaneous injection. The addition of zinc sulfate to the formulations prepared with purified insulin glargine particles further slowed down the drop in blood glucose concentrations.

Product Specifications
SKU :COC27015
AuthorOm Anand Ph.D. and Atul J. Shukla Ph.D.
Number of Pages132
Publishing Year4/23/2010
Edition1 st
Book TypeGenetics (non-medical)
Country of ManufactureIndia
Product BrandVDM Verlag Dr. Müller
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-29 00:00:00