In this book various 2-substituted 4,5-diphenyl imidazoles were prepared by refluxing benzyl with different aromatic aldehydes. The synthesized compounds were characterized by physical data analysis and spectral analysis. The synthesized compounds exhibited analgesic activity against chemically and thermal noxious stimuli. The analgesic activity was found to be significant on the tail-flick model and on the acetic acid induced writhing model. The anti-inflammatory activity was found to be significant on the Carrageenan-induced paw oedema model compared to control. In the Pheretima posthuma, all the synthesized compounds were found to possess anthelmintic activity. The minimum inhibitory concentration (MIC) of the synthesized compounds for the various microbes was determined.