Over the last few years, avian influenza outbreaks have increased exponentially, and the workers of live bird markets (LBMs) are very importantly occupationally exposed population that could potentially play a vital role in the transmission of avian influenza. With this detonation also come a rise in need for understanding the poultry movement and the extent in which this movement is linked periurban with urban areas and the inhabitants within each of these areas. The interaction of humans with poultry provides considerable risk of revelation to virus. Most of the LBMs workers had knowledge about avian influenza and they gathered knowledge through the mass media, and agreed that avian influenza is a serious but preventable disease. Knowledge about mode of transmission, source of infection and preventive practices varied to a great extent. Consequently, a concerted effort is required to enhance knowledge and change the behavior among those most at risk in low-income countries and the precautions necessary to avoid spreading the virus among poultry and humans.