Regeneration of supporting tooth structures is a huge step in managing periodontal defects and preventing tooth loss. These defects have been shown to be at higher risk of disease progression in subjects who had not received systematic periodontal therapy. These bony lesions may not be readily accessible to periodontal debridement, often requiring access flap surgery alone or in combination with bone resective techniques or regenerative procedures . Different modalities of regenerative treatment have been developed. Amongst these, grafting of biomaterials and application of biological agents have been used with varying success to accomplish the reconstruction of lost attachment apparatus in deep intraosseous defects.