Traditional medicines related to plant resources are common in Ethiopia. Yet, the documentation of medicinal plants & its associated knowledge is not complete owing to limited ethnobotanical inventory. Similarly, there has not been any ethnobotanical research carried out in Tehuledere district. So, the study was mainly designed to fill the gap and enrich the limited inventory of medicinal plants by assessing, documenting and preserving traditionally used medicinal plants used in the study area. Over all, a purposive and rapid ethnobotanical survey of traditional medicinal plants in Tehuledere district revealed the strong reliance of the local people on considerable diversity of plant species and locally produced plant remedies for treatment of their healthcare systems.Despite of these, the conservation strategy practiced in the study area is not enough to tackle the erosion of plant species from their habitats. So, In-situ and ex-situ conservation should be implemented; and practitioners should be organized into association to integrally use their knowledge with modern medicine.