Research evidence suggests that the adoption of learner-centered strategy based on the structure and function of the brain can improve learners’ academic performance. Also, there is a need to take cognizance of the fact that, if classrooms are to be places of learning, then the “organ of learning, the brain” must be understood and accommodated. However, there is a paucity of research on the functioning of the brain, as regards Mathematics teaching (and other subjects), particularly in Nigeria. This book therefore explains the latest neuroscientific findings in practical understandable terms and discusses the impact this information has for adopting Brain-based instructional strategy in teaching Mathematics at all levels. The last two chapters of the book contain the practical application of the three instructional techniques of the brain-based learning strategy viz: Relaxed Alertness, Orchestrated Immersion and Active Processing. The information presented in this book is highly invaluable to enhancing students’ optimal learning outcomes in school subjects without any stress. This work is therefore important not only to teachers of Mathematics but indeed all teachers.