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Breast Cancer and The Growth Factors


Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description

Breast cancer is the most common type of malignant tumors and the second most common cause of cancer-related deaths in women worldwide. Breast cancer metastasis is the main cause of death from this disease. Psoriasin (S100A7), a member of the S100 family proteins, is characterized by having calcium-binding domains and is involved in multiple physiopathological processes in the cell such as cell cycle progression and cellular differentiation. Overexpression of S100A7 is a well known factor for inducing progression of the preinvasive to invasive form of breast cancer and its presence is correlated with poor prognosis. Insulin-like Growth Factor (IGF), especially types 1 and 2, has also been shown to play an important role in cellular growth and proliferation of breast and other types of cancer. The purpose of this study was to investigate the cross-talk between S100A7 and IGF-induced signaling mechanism on breast cancer progression and metastasis. We have shown that overexpression of S100A7 in ERα- breast cancer cell lines MDA-MB-231 and SCP6 enhances IGF-induced growth, wound healing, chemotaxis and chemoinvasion.

Product Specifications
SKU :COC84260
AuthorGhassan Tranesh
Number of Pages60
Publishing Year2013-02-16T00:00:00.000
Edition1 st
Book TypeMedicine
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-10-08 00:00:00