Disease outbreaks on dairy farms can be devastating to both animal welfare and farm profitability, with losses in terms of reduced output, increased replacement costs, veterinary costs and labor requirements. Dairy farmers are becoming more aware of how biosecurity programs can help them prevent,or reduce the risk of disease entering and spreading in their herd. Bovine mastitis is the most complex disease condition mainly because of multiple causative agents, poor understanding of the early immune response and complexities associated with mammary epithelial cell damage by both the agents and the host factors. Decreased milk production accounts for approximately 70% of the total cost of mastitis. Additionally, the poor understanding of the underlying phenomenon in subclinical state of the infection complicates the therapeutic interventions.The term mastitis biosecurity program refers to keeping cattle safe from contagious mastitis pathogens, Mastitis can be controlled to a lower level by adopting suitable udder health management programme which intern are based on two main principles viz, elimination of existing infection and prevention of new infection.