Comparison of “C-arm guided” and “aiming device” interlocking nailing of femoral fracture repair in dogs was undertaken. Femoral fracture was more common in Nondescriptive, male and young dogs lesser than 1 year of age. There were no significant variations observed in physiological (Rectal temperature, Respiratory rate and Heart rate), hematological (Hb, TLC, TEC, DLC) and biochemical parameters (Calcium, phosphorus, ALP, AST, ALT). There was a gradual decrease in the pain score from the preoperative day to fourteenth postoperative day, group A dogs showed early weight bearing compared to group B. The immediate post operative radiograph showed exhalent reduction and perfect alignment in both the groups. Surgical procedure of C-arm guided interlocking nailing technique took less time, was minimally invasive and reduced the time of closure of surgical site. But in learning period this procedure requires more time compared to aiming device (Jig) guided interlocking nailing technique. However aiming device (Jig) guided interlocking nailing technique reduced time of exposure to fluoroscopy.