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Ca2+ pumps in the Golgi apparatus

 

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  • Product Description
 

In recent years, additionally to the well-characterized and intensively-studied plasma membrane Ca2+-ATPases (PMCAs) and sarco/endoplasmic reticulum Ca2+-ATPases (SERCAs), new P-type ATPases were identified, the secretory pathway Ca2+-ATPases (SPCAs) which are ion pumps that supply the lumen of the Golgi apparatus with divalent cations. For complete characterization of the human SPCA1 and SPCA2, our study focused on their cell type-specific expression, their distribution in intracellular organelles and their localization in cholesterol-rich membrane microdomains. The Golgi complex is believed to function as a releasable Ca2+ store, besides the major agonist-sensitive intracellular Ca2+ store the endoplasmic reticulum. Therefore, we investigated which part of the Golgi apparatus may contribution to the agonist-induced modulation of cytosolic Ca2+ concentration in human neutrophil granulocytes. In addition, the functional effects of Ca2+ release from the Golgi apparatus on neutrophil polarization and migration was studied.

Product Specifications
SKU :COC22488
AuthorSzilvia Báron
LanguageEnglish
BindingPaperback
Number of Pages96
Publishing Year5/22/2010
ISBN978-3838360577
Edition1 st
Book TypeBiophysics
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-07-28 00:00:00