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Cancer of Uterine Cervix and PTEN tumor suppressor gene

 

Marketed By :  LAP LAMBERT Academic Publishing   Sold By :  Kamal Books International  
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  • Product Description
 

Cancer of uterine cervix is one of the most common malignant diseases affecting women worldwide. It is responsible for almost 20 percent of all female deaths in India with almost 130,000 new cases every year. Multiple alterations are necessary for the development of this cancer in addition to the HPV infection. Comparatively a younger tumor suppressor gene, PTEN, was found to be located on chromosome 10q23.3 with nine exons and is deleted and mutated in a variety of human cancers. PTEN is expressed in normal cervical epithelium, implying that loss of function may have some consequences in cervical cancer. We analyzed carcinoma cases for detection of PTEN promoter methylation, mutation, gene expression and apoptosis. Promoter methylation was detected in 61% cases and found to be correlated with the loss of PTEN expression, suggesting that silencing of PTEN gene definitely contribute in the tumorigenesis of cervical cancer. This work is expected to attract the attention of both the clinicians and researchers in the fields of oncology.

Product Specifications
SKU :COC93972
AuthorM Shabbir Alam and M Moshahid A Rizvi
LanguageEnglish
BindingPaperback
Number of Pages132
Publishing Year2011-02-24T00:00:00.000
ISBN978-3844302875
Edition1 st
Book TypeClinical & internal medicine
Country of ManufactureIndia
Product BrandLAP LAMBERT Academic Publishing
Product Packaging InfoBox
In The Box1 Piece
Product First Available On ClickOnCare.com2015-08-14 00:00:00